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Publicado por Birkhäuser, 1991
ISBN 10: 0817635661ISBN 13: 9780817635664
Librería: HPB-Red, Dallas, TX, Estados Unidos de America
Libro
Hardcover. Condición: Good. Connecting readers with great books since 1972! Used textbooks may not include companion materials such as access codes, etc. May have some wear or writing/highlighting. We ship orders daily and Customer Service is our top priority!.
Publicado por Birkhäuser, 1996
ISBN 10: 0817638792ISBN 13: 9780817638795
Librería: HPB-Red, Dallas, TX, Estados Unidos de America
Libro
hardcover. Condición: Good. Connecting readers with great books since 1972! Used textbooks may not include companion materials such as access codes, etc. May have some wear or writing/highlighting. We ship orders daily and Customer Service is our top priority!.
Publicado por Taylor & Francis, 1990, 1990
Librería: First Choice Books, Coeurd'Alene, ID, Estados Unidos de America
HB--VG; black glossy cover. contains photos, charts, tables, diagrams; references;
Publicado por Birkhauser, 1991
ISBN 10: 0817635661ISBN 13: 9780817635664
Librería: K & L KICKIN' BOOKS, Corinth, TX, Estados Unidos de America
Libro Original o primera edición
Hardcover. Condición: Very Good. Estado de la sobrecubierta: No Dj. First Edition. B&R-158Ex-college library with usual library features.
Publicado por Birkhäuser, 1991
ISBN 10: 0817635661ISBN 13: 9780817635664
Librería: Midtown Scholar Bookstore, Harrisburg, PA, Estados Unidos de America
Libro
Hardcover. Condición: Very Good. Very Good - Crisp, clean, unread book with some shelfwear/edgewear, may have a remainder mark - NICE Standard-sized.
Publicado por Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: Lucky's Textbooks, Dallas, TX, Estados Unidos de America
Libro
Condición: New.
Publicado por Birkhäuser, 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Librería: Lucky's Textbooks, Dallas, TX, Estados Unidos de America
Libro
Condición: New.
Publicado por Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: GreatBookPrices, Columbia, MD, Estados Unidos de America
Libro
Condición: New.
Publicado por Birkhäuser, 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Librería: GreatBookPrices, Columbia, MD, Estados Unidos de America
Libro
Condición: New.
Publicado por Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: booksXpress, Bayonne, NJ, Estados Unidos de America
Libro Impresión bajo demanda
Soft Cover. Condición: new. This item is printed on demand.
Publicado por Birkhäuser, 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Librería: booksXpress, Bayonne, NJ, Estados Unidos de America
Libro
Soft Cover. Condición: new.
Publicado por Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: Ria Christie Collections, Uxbridge, Reino Unido
Libro Impresión bajo demanda
Condición: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book.
Publicado por Birkhauser
ISBN 10: 0817635661ISBN 13: 9780817635664
Librería: Romtrade Corp., STERLING HEIGHTS, MI, Estados Unidos de America
Libro
Condición: New. Brand New Original US Edition.We Ship to PO BOX Address also. EXPEDITED shipping option also available for faster delivery.This item may ship from the US or other locations in India depending on your location and availability.
Publicado por Birkhäuser Boston, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: Buchpark, Trebbin, Alemania
Libro
Condición: Sehr gut. Zustand: Sehr gut - Gepflegter, sauberer Zustand. | Seiten: 528 | Sprache: Englisch.
Publicado por Birkhauser
ISBN 10: 0817635661ISBN 13: 9780817635664
Librería: SMASS Sellers, IRVING, TX, Estados Unidos de America
Libro
Condición: New. Brand New Original US Edition. Customer service! Satisfaction Guaranteed. This item may ship from the US or our Overseas warehouse depending on your location and stock availability. We Ship to PO BOX Location also.
Publicado por Birkhäuser Boston Mai 2012, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Alemania
Libro Impresión bajo demanda
Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis. 528 pp. Englisch.
Publicado por Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: GreatBookPricesUK, Castle Donington, DERBY, Reino Unido
Libro
Condición: New.
Publicado por Birkhäuser, 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Librería: GreatBookPricesUK, Castle Donington, DERBY, Reino Unido
Libro
Condición: New.
Publicado por Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: Revaluation Books, Exeter, Reino Unido
Libro
Paperback. Condición: Brand New. reprint edition. 509 pages. 9.00x6.00x1.25 inches. In Stock.
Publicado por Springer-Verlag New York Inc., 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Librería: Kennys Bookshop and Art Galleries Ltd., Galway, GY, Irlanda
Libro
Condición: New. Series: Advances in Alzheimer Disease Therapy. Num Pages: 504 pages, 23 black & white illustrations, biography. BIC Classification: MJND. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 26. Weight in Grams: 771. . 2013. Softcover reprint of the original 1st ed. 1991. Paperback. . . . .
Publicado por Birkh?user, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: Kennys Bookshop and Art Galleries Ltd., Galway, GY, Irlanda
Libro
Condición: New. 2012. Softcover reprint of the original 1st ed. 1994. paperback. . . . . .
Publicado por Birkhäuser Boston, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: AHA-BUCH GmbH, Einbeck, Alemania
Libro
Taschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.
Publicado por Birkhäuser Boston, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: moluna, Greven, Alemania
Libro Impresión bajo demanda
Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critic.
Publicado por Birkhäuser Boston, 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Librería: moluna, Greven, Alemania
Libro Impresión bajo demanda
Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Springer Book Archives.
Publicado por Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: Kennys Bookstore, Olney, MD, Estados Unidos de America
Libro
Condición: New. 2012. Softcover reprint of the original 1st ed. 1994. paperback. . . . . . Books ship from the US and Ireland.
Publicado por Springer-Verlag New York Inc., 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Librería: Kennys Bookstore, Olney, MD, Estados Unidos de America
Libro
Condición: New. Series: Advances in Alzheimer Disease Therapy. Num Pages: 504 pages, 23 black & white illustrations, biography. BIC Classification: MJND. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 26. Weight in Grams: 771. . 2013. Softcover reprint of the original 1st ed. 1991. Paperback. . . . . Books ship from the US and Ireland.
Publicado por Birkhauser 2012-05, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: Chiron Media, Wallingford, Reino Unido
Libro
PF. Condición: New.
Publicado por Birkhäuser, 1996
ISBN 10: 0817638792ISBN 13: 9780817638795
Librería: Romtrade Corp., STERLING HEIGHTS, MI, Estados Unidos de America
Libro
Condición: New. Brand New Original US Edition.We Ship to PO BOX Address also. EXPEDITED shipping option also available for faster delivery.This item may ship from the US or other locations in India depending on your location and availability.
Publicado por Birkhäuser, 1996
ISBN 10: 0817638792ISBN 13: 9780817638795
Librería: SMASS Sellers, IRVING, TX, Estados Unidos de America
Libro
Condición: New. Brand New Original US Edition. Customer service! Satisfaction Guaranteed. This item may ship from the US or our Overseas warehouse depending on your location and stock availability. We Ship to PO BOX Location also.
Publicado por Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Librería: GreatBookPricesUK, Castle Donington, DERBY, Reino Unido
Libro
Condición: As New. Unread book in perfect condition.